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摘要:本发明属于医药技术领域,公开了一种白果内酯及其衍生物在治疗脑水肿特别是大脑缺血引起的脑水肿中的应用。研究结果表明,白果内酯能够减少永久性中动脉闭塞模型动物的脑组织水含量和梗死病灶面积。白果内酯减弱脑水肿形成的机制是在不同的阶段降低水通道蛋白1、4、9的mRNA转录和蛋白质的表达水平。白果内酯可以和药学上可以接受的载体结合制成临床上可以接受的注射剂、透皮制剂或口服给药制剂用于治疗脑水肿。
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Abstract: The invention belongs to the technical field of medicament, and discloses a bilobalide and a use of derivative thereof in treating encephaledema, especially encephaledema caused by cerebral ischemia. Research results show that the bilobalide can reduce the brain tissue water content and the cerebral infarction area of a permanent medium-sized arterial occlusion model animal. The mechanism of the bilobalide for weakening the formation of encephaledema is to lower the mRNA transcription level of aquaporin 1, 4 and 9 and the expression level of protein in different stages. The bilobalide can be combined with a pharmaceutically acceptable carrier to be prepared into a clinically acceptable injection, a transdermal preparation or an oral administration preparation for treating the encephaledema.
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申请人: 沈阳药科大学
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Applicant: UNIV SHENYANG PHARMACEUTICAL
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地址: 110016 辽宁省沈阳市沈河区********(隐藏)
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发明(设计)人: 游松 秦斌 秦海明 贾娴 陈奕南 翟兴雯 徐慰倬
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Inventor: YINAN CHEN; XIAN JIA; BIN QIN; HAIMING QIN; WEIZHUO XU; SONG YOU; XINGWEN ZHAI
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主分类号: A61K31/365(2006.01)I
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分类号: A61K31/365(2006.01)I A61P9/10(2006.01)I A61P7/10(2006.01)I
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