Abstract: The invention relates to a control circuit and a vehicle control device. The control circuit comprises a key control unit, a disassembly detection unit and a self-destroying power source unit. The disassembly detection unit is electrically connected with the self-destroying power source unit and used for detecting whether the vehicle control device is disassembled or not, when the vehicle control device is disassembled, the disassembly detection unit is further used for generating a self-destroying command and sending the self-destroying command to the self-destroying power source unit, and when the self-destroying command is received, the self-destroying power source unit is further used for being electrically connected with the key control unit, generating a target self-destroying signal according to the self-destroying command and sending the target self-destroying signal to the key control unit to enable the key control unit to be self-destroyed, wherein the target self-destroying signal comprises a target self-destroying voltage signal or a target self-destroying current signal. According to the control circuit and the vehicle control device, when the vehicle control device is disassembled, the key control unit is damaged, a vehicle cannot be started, an automatic anti-theft function can be effectively achieved, and the safety of the vehicle is improved.
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