CN200510112917
CN1948475A
微信扫码查看/分享专利
|
摘要:本发明涉及新的可用于治疗艾滋病的重组表达载体、经改造细胞(特别是造血干细胞)和方法。本发明提供重组表达载体和经改造细胞(特别是造血干细胞),其可表达:(1)MGMT(P140K)基因;和(2)多个(特别是靶向HIV的)SIRNA和/或MIRNAS和/或核酶和/或反义寡核苷酸。本发明还提供治疗HIV感染的方法,包括(1)制备本发明的细胞,然后将其移植到HIV感染患者体内;和(2)进行适当的BG/BCNU治疗。
|
Abstract: This invention involves a new treatment for AIDS recombinant expression vector, a modified cells (especially hematopoietic stem cells), and methods. The invention provides recombinant expression vector and modified cells (especially hematopoietic stem cells), its expression: (1) MGMT (P140K) gene; and (2) various (especially targeting HIV) siRNA and / or miRNAs and / or ribozymes, and / or anti - oligonucleotides. The invention also provides treatment of HIV infection, including (1) Preparation of the cell of this invention, then transplant to their patients with HIV infection; and (2) BG/BCNU appropriate treatment.
|
申请人: 厦门大学
|
Applicant: UNIV XIAMEN[CN]
|
地址: 361005福建省********(隐藏)
|
发明(设计)人: 夏宁邵 史长平 林圣彩
|
Inventor: XIA NINGSHAO SHI[CN]
|
主分类号: C12N15/09(2006.01)I
|
分类号: C12N15/09(2006.01)I C12N15/63(2006.01)I C12N15/85(2006.01)I C12N15/86(2006.01)I C12N15/867(2006.01)I C12N5/10(2006.01)I A61P37/00(2006.01)I A61K35/12(2006.01)I
|
|